Clavulanic Acid

SKU: orb1705935

Description

Clavulanic Acid (RX-10100) is a β-lactamase inhibitor isolated from Streptomyces clavuligerus. It is used in research to study bacterial resistance mechanisms and is commonly combined with β-lactam antibiotics for in vitro susceptibility testing and in vivo infection model studies.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58001-44-8
• MW: 199.16
• Purity: ≥98% (May vary between batches)
• Formula: C₈H₉NO₅
• SMILES: [H][C@@]12CC(=O)N1[C@@H](C(O)=O)\C(O2)=C\CO
• Target: Antibiotic,Antibacterial,Antifungal
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.02 mM);DMSO:10 mg/mL (50.21 mM)

Bioactivity

• In Vivo:
  In C57BL/6 mice with Pseudomonas aeruginosa pneumonia, intraperitoneal injection of clavulanic acid (13 mg/kg) reduces bacterial burden in the lungs. In C57BL/6 mice infected with Ab51, intraperitoneal injection of clavulanic acid (13 mg/kg) shows a half-life (t1/2) of 6.69 hours and an area under the curve (AUC) of 4.03 mg·h/L in a lung infection model. In a rat model of carrageenan-induced paw edema, intraperitoneal injection of clavulanic acid (100-300 mg/kg) exhibits anti-inflammatory effects.
• In Vitro:
  Clavulanic acid exhibits synergistic antibacterial activity with ampicillin against microorganisms producing β-lactamase. Clavulanic acid inhibits strains Ab11 and Ab51 with a minimum inhibitory concentration (MIC) ranging from 2 to 8 μg/mL.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clavulanic Acid, BRL 14151, BRL14151, BRL-14151, Fungal, MM 14151, MM14151, MM-14151, RX-10100, β-Lactamase

Compound Identifiers

PubChem CID

5280980