CID 16020046

SKU: orb1302824

Description

CID 16020046 is a potent and selective antagonist of the GPR55 receptor, demonstrating an IC50 of 0.15 μM against its constitutive activity in a yeast-based assay. This small molecule is a valuable research tool for investigating the role of GPR55 in various physiological and pathological processes, including cancer cell proliferation and neuropathic pain, in both in vitro and in vivo studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 834903-43-4
• MW: 425.44
• Purity: 99.67% (May vary between batches)
• Formula: C₂₅H₁₉N₃O₄
• SMILES: Cc1ccc(cc1)-c1n[nH]c2C(=O)N(C(c12)c1cccc(O)c1)c1ccc(cc1)C(O)=O
• Target: Cannabinoid Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.7 mM);DMSO:55 mg/mL (129.28 mM)

Bioactivity

• Target IC50:
  GPR55:0.15 μM
• In Vitro:
  In yeast cells expressing human GPR55, CID16020046 inhibited agonist-induced receptor activation. In human embryonic kidney (HEK293) cells stably expressing human GPR55, CID16020046 behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2 (CB1 or CB2). CID16020046 dose-dependently inhibited lysophosphatidylinositol (LPI)-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor κ of activated B cells (NF-κB) and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, CID 16020046, CID16020046, CID-16020046, acetylcholinesterase, C390-0219, Ca2+, CannabinoidReceptor, Cannabinoid Receptor, KCNH2, m-opioid, inhibit, lysophosphatidylinositol, LPI, Inhibitor, hERG, healing, HEK, HMVEC, GPR55, function, G protein-coupled receptor 55, endothelial, ERK1/2, platelet, phosphorylation, wound

Compound Identifiers

PubChem CID

16020046