CB2 receptor agonist 2

SKU: orb1306124

Description

CB2 receptor agonist 2 (ZINC72105556) is a potent and selective CB2 receptor agonist with a Ki of 8.5 nM. This high-affinity ligand is a valuable research tool for studying CB2-mediated pathways in vitro and in vivo within immunology and neuroinflammation research.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1314230-75-5
• MW: 488.62
• Purity: 98.07% (May vary between batches)
• Formula: C₃₀H₃₆N₂O₄
• SMILES: N(C(=O)C=1C(=O)C=2C(N(CCCCC)C1)=C(OC)C=C(C2)C3=CC=CO3)C45CC6CC(C4)CC(C5)C6
• Target: Cannabinoid Receptor
• Solubility: DMSO:3 mg/mL (6.14 mM)

Bioactivity

• Target IC50:
  CB2:8.5 nM (Ki)
• In Vivo:
  CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is highly potent, showing maximal effect at 1 mg/kg, with antihyperalgesic effects that are effective in the first phase of the nocifensive response and are strongly reduced by AM630, a CB2-selective antagonist/inverse agonist .
• In Vitro:
  CB2 receptor agonist 2 (compound 4g) (1 μM, 72 hours) exhibits minimal to no cytotoxicity in Hep-G2 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB2R, CB2 receptor agonist 2, CannabinoidReceptor, Cannabinoid Receptor, 4-Quinolone-3-Carboxamide Furan CB2 Agonist, ZINC 72105556, ZINC72105556, ZINC-72105556

Compound Identifiers

PubChem CID

53387350