CB1 inverse agonist 1

SKU: orb1710145

Description

MRL-650 is a potent and selective CB1 receptor inverse agonist with an IC50 of 7.5 nM for CB1 versus 4100 nM for CB2. This orally bioavailable compound exhibits anorexigenic effects in vivo and is a valuable tool for studying cannabinoid receptor pharmacology in metabolic and appetite regulation research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 852315-00-5
• MW: 514.79
• Purity: 99.92% (May vary between batches)
• Formula: C₂₅H₁₈Cl₃N₃O₃
• SMILES: N(C(C)=O)C=1C=2C(=NC(=C(C2)C3=CC=C(Cl)C=C3)C4=C(Cl)C=C(Cl)C=C4)N(C)C(=O)C1C(C)=O
• Target: Cannabinoid Receptor
• Solubility: DMSO:45 mg/mL (87.41 mM)

Bioactivity

• Target IC50:
  CB2:4100 nM|CB1:7.5 nM
• In Vivo:
  CB1 inverse agonist 1 (0.3-3 mg/kg) dose-dependently inhibits feeding in a manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CannabinoidReceptor, Cannabinoid Receptor, CB1, CB1 inverse agonist 1, CB2, MRL 650, MRL650, MRL-650

Compound Identifiers

PubChem CID

11386747