Biapenem

SKU: orb1300791

Description

Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with broad-spectrum activity comparable to imipenem. It exhibits enhanced stability against renal dehydropeptidase-I and reduced neurotoxicity. This compound is utilized in microbiological and pharmacological research, including in vitro susceptibility testing and in vivo efficacy studies against various bacterial infections.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 120410-24-4
• MW: 350.39
• Purity: 99.57%
• Formula: C₁₅H₁₈N₄O₄S
• SMILES: C([O-])(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1SC3CN4[N+](C3)=CN=C4)[H]
• Target: Antibiotic,Antibacterial
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vivo:
  Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa.
• In Vitro:
  Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LJC10627, LJC-10627, LJC 10627, L 627, inhibit, Omegacin, L627, L-627, Inhibitor, CLI 86815, CLI86815, CLI-86815, Bacterial, Antibiotic, Antibacterial, Biapenem, Biapenern, wcin, ωcin

Compound Identifiers

PubChem CID

71339