BAY 60-6583

SKU: orb1707590

Description

BAY 60-6583 is a potent and selective agonist of the adenosine A2B receptor (EC50 = 3 nM), demonstrating cardioprotective effects in myocardial ischemia models. Its species-specific binding affinity (Ki: mouse 750 nM, rabbit 340 nM, dog 330 nM) supports its use in cardiovascular and inflammatory disease research across in vitro and in vivo studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 910487-58-0
• MW: 379.44
• Purity: 99.80% (May vary between batches)
• Formula: C₁₉H₁₇N₅O₂S
• SMILES: NC(=O)CSc1nc(N)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N
• Target: Adenosine Receptor
• Solubility: DMSO:90 mg/mL (237.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.54 mM)

Bioactivity

• Target IC50:
  A2BAR (rabbit):340 nM|A2BAR (dog):330 nM|A2BAR (mouse):750 nM|A2B:3 nM(EC50)
• In Vivo:
  BAY 60-6583 (100 mg/kg; intravenous injection; rabbit) administered just before reperfusion, diminishes the infarction area in ischemic rabbit hearts. BAY 60-6583 (2 mg/kg; intravenous injection; mice) attenuates LPS-induced lung injury, pre-treatment with this compound can significantly decrease LPS-increased, IL-6 levels in WT mice.
• In Vitro:
  BAY 60-6583(0-10 μM) exhibits the maximum agonist effect of BAY 60-6583 in the absence of siRNA is 68 %. BAY 60-6583 (5 μM; 24 h) induces a rise in cell accumulation within the G1 phase while concurrently reducing the G2/M phase in RAW264.7 preosteoclasts. Additionally, under the same conditions, BAY 60-6583 specifically impedes Akt activation triggered by M-CSF, with no discernible impact on M-CSF-induced ERK1/2 activation in RAW264.7 preosteoclasts.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY 60 6583, BAY 606583, BAY 60-6583, Adenosine Receptor, AdenosineReceptor, A1, A2A, A2B, A3

Compound Identifiers

PubChem CID

11717831