Azelaprag

SKU: orb1707602

Description

Azelaprag is a potent apelin receptor agonist (EC50 = 0.32 nM) used in research for nervous system and cardiovascular diseases. Studies in vitro and in vivo explore its potential in models of heart failure, pulmonary hypertension, and metabolic disorders.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2049980-18-7
• MW: 523.61
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₂₉N₇O₄S
• SMILES: N(S([C@H]([C@H](C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC
• Target: Apelin receptor
• Solubility: DMSO:69.3 mg/mL (132.35 mM)

Bioactivity

• Target IC50:
  apelin receptor:0.32 nM (EC50)|RAGE:12.7 ± 7.6 nM (kd)
• In Vivo:
  METHODS: To investigate the effect of Azelaprag on cardiac function, Azelaprag (1mg/kg/min) was infused intravenously at an acute time point in a rat model of impaired metabolic function. RESULTS: Azelaprag increased cardiac reserve during Dobutamine challenge in a metabolically impaired rat model.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMG986, AMG-986, AMG 986, Apelin receptor, Apelinreceptor, Azelaprag

Compound Identifiers

PubChem CID

122702529