Anti-IGF-1R(teprotumumab biosimilar) mAb

• Catalog Number: orb1826913
• Category: Antibodies
• Description: Anti-IGF-1R(teprotumumab biosimilar) mAb
• Target: IGF-1R
• Clonality: Monoclonal
• Species/Host: Human
• Isotype: IgG1(E239D, M241L)
• Conjugation: Unconjugated
• Reactivity: Human
• Purification: Purified from cell culture supernatant by affinity chromatography
• UniProt ID: P08069
• Tested applications: FC
• Dilution range: Flow Cyt 1:100
• Application notes: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
• Antibody Type: Biosimilar Antibody
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: CD221, IGFIR, IGFR, JTK13
• Note: For research use only

IGF-1R protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with 1 μg/mL Anti-IGF-1R (teprotumumab biosimilar) mAb (orb1826913) on Expi293 cells transfected with human IGF-1R (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).

Flow cytometry analysis of antigen binding of anti-human IGF-1R mAb (orb1826913). (A) orb1826913 does not bind to Jurkat cells that do not express IGF-1R. (B) A clear peak shift of orb1826913 was seen compared to the control when incubated with IGF-1R-expressing Hela cells, indicating strong binding of orb1826913 to IGF-1R. Antibodies were incubated at 5 μg/mL.

Flow cytometry analysis of antigen binding of anti-human IGF-1R mAb (orb1826913). (A) orb1826913 does not bind to Jurkat cells that do not express IGF-1R. (B) A clear peak shift of orb1826913 was seen compared to the control when incubated with IGF-1R-expressing MCF-7 cells, indicating strong binding of orb1826913 to IGF-1R. Antibodies were incubated at 5 μg/mL.