Amikacin disulfate

SKU: orb1300817

Description

Amikacin disulfate, also known as BAY-416651 sulfate, is a semi-synthetic derivative of kanamycin A. This aminoglycoside antibiotic is widely used in research for its potent activity against Gram-negative bacteria in both in vitro susceptibility assays and in vivo infection model studies.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 39831-55-5
• MW: 781.76
• Purity: 99.88% (May vary between batches)
• Formula: C₂₂H₄₃N₅O₁₃·2H₂O₄S
• SMILES: O=S(O)(O)=O.NCC[C@H](O)C(N[C@H](C[C@@H]([C@H]([C@@H]1O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CN)N)[C@@H]1O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)N)O)CO)=O.O=S(O)(O)=O
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:Insoluble;H2O:100 mg/mL (127.92 mM)

Bioactivity

• In Vivo:
  Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly.
• In Vitro:
  Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Amikacin is active in vitro against Pseudomonas species, Escherichia coli, Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii. In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

protein, Pierami, ribosomal, synthesis, aminoglycosides, Antibiotic, Antimicrobial, Bacterial, bacillary, BB-K8, BAY416651 Sulfate, BAY-416651 Sulfate, BAY-416651 sulfate, BAY 41-6551 disulfate, BAY 416651 Sulfate, Amikacin, Amikacin disulfate, Amikacin Disulfate, Amikacin Sulfate, Amikacin sulfate, 16S rRNA, inhibit, Inhibitor, kanamycin, infections, ototoxic, Gram-negative

Chemical Structure of Amikacin disulfate.

Compound Identifiers

PubChem CID

38351