Amezinium methylsulfate

SKU: orb1301885

Description

Amezinium methylsulfate (Lu-1631) is a sympathomimetic agent that acts as an α- and β1-adrenoceptor agonist while also blocking the neuronal reuptake of noradrenaline and tyramine. It is utilized in pharmacological research to study cardiovascular responses and adrenergic mechanisms in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 30578-37-1
• MW: 313.33
• Purity: 99.99% (May vary between batches)
• Formula: C₁₂H₁₅N₃O₅S
• SMILES: COS([O-])(=O)=O.COc1cc(N)cn[n+]1-c1ccccc1
• Target: Adrenergic Receptor
• Solubility: DMSO:50 mg/mL (159.58 mM)

Bioactivity

• In Vivo:
  In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %) . The reduction ratio of FTBF was significantly increased by amezimium [placebo, 75.9%; amezinium, 85.1%; midodrine, 78.1%]. The infusion rate of noradrenaline producing a half-maximum venoconstriction was significantly decreased by amezinium (placebo, 40.6 ng/min; amezinium, 21.0 ng/min) .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adrenergic Receptor, AdrenergicReceptor, Amezinium, Amezinium (methylsulfate), Amezinium methylsulfate, Amezinium metilsulfate, Beta Receptor, Lu 1631, Lu1631, Lu-1631, methylsulfate, inhibit, Inhibitor, α-adrenergic receptor, β1-adrenergic receptor

Compound Identifiers

PubChem CID

71926