AM6545

SKU: orb1704695

Description

AM6545 is a selective, peripherally restricted CB1 antagonist with CB2 inhibitory activity. It has demonstrated efficacy in ameliorating obesity and improving adipokine profiles in monosodium glutamate-induced obese mouse models, making it a valuable research tool for studying metabolic disorders such as obesity and diabetes.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1245626-05-4
• MW: 556.46
• Purity: 97.03%
• Formula: C₂₆H₂₃Cl₂N₅O₃S
• SMILES: N#CCCC#CC=1C=CC(=CC1)C2=C(C(=NN2C3=CC=C(Cl)C=C3Cl)C(=O)NN4CCS(=O)(=O)CC4)C
• Target: Cannabinoid Receptor
• Solubility: DMSO:5 mg/mL (8.99 mM)

Bioactivity

• In Vivo:
  METHODS: AM6545 (1 mg/kg, intraperitoneal injection) and CNO (3 mg/kg) were administered to mice, and the discrimination index values ​​of NORT in the vagus nerve were observed 48 hours after administration. RESULTS: AM6545 can improve memory consolidation through an adrenergic mechanism involving vagal afferent nerves.
• In Vitro:
  METHODS: AM6545 (0.5 mM) was used to treat 3T3-L1 adipocytes to examine possible beiging effects of peripheral CB1R antagonist treatment, and the expression of key beiging markers was examined. RESULTS: AM6545 significantly increased many genes involved in adipocyte coagulation, including peroxisome proliferator-activated receptor gamma coactivator 1-α (Pgc1α), PR domain containing 16 (Prdm16), and uncoupling protein 1 (Ucp1), cell death-inducing DNA fragmentation factor α-like effector A (Cieda), long-chain fatty acid protein 3 (Elovl3), tumor necrosis factor receptor superfamily member 9 (Cd137), T-box transcription factor ( Tbx1), transmembrane protein 26 (Tmem26), cbp/p300 interacting transactivator 1, fibroid/endoplasmic reticulum calcium 2+-ATPase 2b (Serca2b), ryanodine receptor 2 (Ryr2).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AM6545, AM-6545, AM 6545, Cannabinoid Receptor, CannabinoidReceptor, CB1R, CB2R

Compound Identifiers

PubChem CID

46912919