Alizarin

SKU: orb1304810

Description

Alizarin (Mordant Red 11), a natural anthraquinone from madder root, acts as a cytochrome P450 inhibitor with selectivity for CYP1B1 (IC50=2.7 µM) over CYP1A1 and CYP1A2. It is utilized in biochemical research to study the role of these enzymes in xenobiotic metabolism and carcinogenesis in vitro.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 72-48-0
• MW: 240.21
• Purity: 99.79% (May vary between batches)
• Formula: C₁₄H₈O₄
• SMILES: OC1=C(O)C2=C(C=C1)C(=O)C1=CC=CC=C1C2=O
• Target: NF-κB,Cytochromes P450,PI3K,VEGFR,AMPK,Akt
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:31.6 mg/mL (131.55 mM)

Bioactivity

• Target IC50:
  CYP1A2:10.0 μM|CYP1B1:2.7 μM|CYP1A1:6.2 μM
• In Vivo:
  In rat liver microsomes, Alizarin can inhibit the oxidation of phenoxy radicals, superoxide anion radicals, and lipid peroxides.
• In Vitro:
  Within the bodies of poisoned animals, Alizarin has been shown to reduce the levels of hepatic mercapturic acid conjugates and serum alanine transaminase (ALT) levels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP1A1, CYP1A2, CYP1B1, Anthraquinonic, Alizarin, Inhibitor, inhibit, Mordant Red 11

Compound Identifiers

PubChem CID

6293