Agomelatine (L(+)-Tartaric acid)

SKU: orb1710471

Description

Agomelatine (L(+)-Tartaric acid) is a potent MT1/MT2 receptor agonist and a selective 5-HT2C receptor antagonist. This dual activity makes it a valuable research tool for investigating circadian rhythms, mood disorders, and neuropharmacology in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 824393-18-2
• MW: 393.39
• Purity: 99.79% (May vary between batches)
• Formula: C₁₉H₂₃NO₈
• SMILES: [C@@H]([C@H](C(O)=O)O)(C(O)=O)O.C(CNC(C)=O)C=1C2=C(C=CC(OC)=C2)C=CC1
• Target: 5-HT Receptor,MT Receptor
• Solubility: DMSO:80 mg/mL (203.36 mM)

Bioactivity

• Target IC50:
  MT1 (human, CHO cells):0.1 nM (Ki)|5-HT2C receptor (human):6.2 (pKi)|MT2 (human, CHO cells):0.12 nM (Ki)|5-HT2C receptor (native porcine):6.4 (pKi)|MT1 (human):0.06 nM (ki)|MT2 (human):0.27 nM (Ki)
• In Vivo:
  Agomelatine (L(+)-Tartaric acid) (25, 50, or 75 mg/kg, intraperitoneal injection) exhibits antioxidant activity in strychnine- or pilocarpine-induced seizure models in mice. However, compared with the control group, Agomelatine (L(+)-Tartaric acid) did not demonstrate any antioxidant effects on oxidative stress-related indicators in pentylenetetrazole (PTZ)- or picrotoxin (PTX)-induced seizure models .
• In Vitro:
  In the experimental system where human MT1 receptors (hMT1) and human MT2 receptors (hMT2) are expressed on the cell membranes of CHO cells (or HEK cells), the EC₅₀ values of Agomelatine (L(+)-Tartaric acid) acting on CHO-hMT1 and CHO-hMT2 are 1.6±0.4 nM and 0.10±0.04 nM, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

human 5-HT2C receptor, HEK-hMT1, HEK-hMT2, native porcine 5-HT2C receptor, CHO-hMT1, CHO-hMT2, 5HT Receptor, 5HTReceptor, Agomelatine (L(+) Tartaric acid), Agomelatine (L(+)Tartaric acid), Agomelatine (LTartaric acid), S-20098 L(+)-Tartaric acid, S-20098 LTartaric acid

Compound Identifiers

PubChem CID

78357824