Adenosine amine congener

SKU: orb1299595

Description

Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist. It is a research tool used in vitro and in vivo to study cardiac protection, neuroprotection, and the modulation of neuronal activity.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 96760-69-9
• MW: 576.6
• Purity: 98.29% (May vary between batches)
• Formula: C₂₈H₃₂N₈O₆
• SMILES: NCCNC(=O)Cc1ccc(NC(=O)Cc2ccc(Nc3ncnc4n(cnc34)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)cc1
• Target: Adenosine Receptor
• Solubility: DMSO:31.25 mg/mL (54.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.47 mM)

Bioactivity

• In Vivo:
  Adenosine amine congener (ADAC) was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8-28 kHz). Pharmacokinetic studies demonstrated a short (5 min) half-life of ADAC in plasma after intravenous administration without detection of degradation products.
• Animal Research:
  Adenosine amine congener (ADAC) (25-300 μg/kg) was administered intraperitoneally to Wistar rats (8-10 weeks old) at intervals (6-72 hours) after exposure to traumatic noise (8-16 kHz, 110 dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P1 receptor, systemic, inhibit, loss, neuroprotective, otoprotective, injury, hearing, Inhibitor, A1, A1-adenosine, AdenosineReceptor, Adenosine amine congener, ADAC, Adenosine Receptor, Ca2+, apoptotic, Cochlear

Compound Identifiers

PubChem CID

126054