A 582941 HCl (848591-90-2(free base))

SKU: orb1219600

Description

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS). In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation. A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit. A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.

Key Properties

• Target: AChR
• Molecular Weight: 316.83
• Purity: >98% (HPLC)
• CAS Number: ——
• Formula: C₁₇H₂₁ClN₄
• SMILES: Cl.CN1C[C@H]2CN(C[C@H]2C1)c3ccc(nn3)c4ccccc4

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR