A-582941 dihydrochloride

SKU: orb1306121

Description

A-582941 dihydrochloride is a selective partial agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR). This compound is utilized in neuroscience research to investigate receptor function and has been applied in both in vitro and in vivo studies exploring cognitive processes and neuropsychiatric disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 848591-90-2
• MW: 353.29
• Purity: 99.55% (May vary between batches)
• Formula: C₁₇H₂₂Cl₂N₄
• SMILES: CN(CC1C2)CC1CN2C3=NN=C(C4=CC=CC=C4)C=C3.Cl.Cl
• Target: 5-HT Receptor,AChR
• Solubility: DMSO:55 mg/mL (155.68 mM)

Bioactivity

• Target IC50:
  5-HT3 receptor:150 nM (Ki)|α7 nAChR:10.8 nM (Ki, for rat α7 receptors)|α7 nAChR:16.7 nM (Ki, for human α7 receptors)
• In Vivo:
  A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs. In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation. A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit. A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

deficits, cognitive, 5-HT3, A 582941, 5-HT Receptor, 5HT Receptor, A582941, A-582941, A-582941 Dihydrochloride, 5HTReceptor, partial, neurodegenerative, nAChR, α7 nAChR

Compound Identifiers

PubChem CID

67162119