84-B10

SKU: orb1982154

Description

84-B10 is a protective agent against cisplatin-induced nephrotoxicity. It mitigates kidney damage by counteracting ferroptosis, reducing lipid peroxidation and mitochondrial ROS, while restoring antioxidant defenses. This small molecule is utilized in research models, both in vitro and in vivo, to study acute kidney injury and ferroptotic cell death pathways.

Research Area

Cell Biology

Key Properties

• CAS Number: 698346-43-9
• MW: 473.44
• Purity: 99.76%
• Formula: C₂₅H₂₂F₃NO₅
• SMILES: O=C(O)CC(C=1C=CC=CC1)CC(=O)NC2=CC(=CC=C2OC3=CC=C(OC)C=C3)C(F)(F)F
• Target: Ferroptosis
• Solubility: DMSO:80 mg/mL (168.98 mM);H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.22 mM)

Bioactivity

• In Vivo:
  84-B10 plays a protective role in cisplatin induced acute kidney injury, but has no tumor-promoting effect.
• In Vitro:
  84-B10 (10-100 μM,2 h) inhibited cisplatin induced iron death in renal tubular epithelial cells in a dose-dependent manner. Treatment with 84-B10 (40 μM, 2 hours) restored cisplatin induced mitochondrial structural damage and dysfunction. 84-B10 (40 μM, 2 hours) mitigated MTROS-induced oxidative stress in cisplatin-induced AKI. 84-B10 (40 μM, 2 hours) alleviates cisplatin induced epithelial cell damage by eliminating mtROS and restoring mitochondrial homeostasis .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

2812813