5-Iodotubercidin

SKU: orb1223175

Description

5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

Key Properties

• CAS Number: 24386-93-4
• MW: 392.15
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₃IN₄O₄
• SMILES: Nc1ncnc2c1c(I)cn2[C@@H]1O[C@H](CO)[C@H](O)C1O
• Target: EGFR
• Solubility: DMSO : ≥ 49 mg/mL; 124.95 mM

Bioactivity

• In Vivo:
  5-Iodotubercidin (1 mL/kg, i.p.) is in agreement with activity observed against bicuculline-induced seizures following local administration of the AKI into the prepiriform cortex.
• In Vitro:
  5-Iodotubercidin (NSC 113939) inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC, and the IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively.5-Iodotubercidin (20 μM) causes an important decrease in ATP concentration, and a concomitant smaller increase in AMP concentration. 5-Iodotubercidin decreases the activity of ACC and the rates of synthesis of fatty acids and cholesterol. In line with the iodotubercidin-mediated inhibition of ACC, 5-iodotubercidin induces a marked decrease in the intracellular concentration of malonyl-CoA.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 113939 | 5-ITu

Quick Database Links

Gene Symbol

EGFR