5-Aminosalicylic Acid

SKU: orb1310419

Description

5-Aminosalicylic Acid (5-ASA) is a small molecule acting as a specific PPARγ agonist with additional inhibitory effects on PAK1, NF-κB, and osteopontin. This multi-target activity underpins its utility in research on inflammation and cancer, supported by evidence from both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 89-57-6
• MW: 153.14
• Purity: 99.98% (May vary between batches)
• Formula: C₇H₇NO₃
• SMILES: NC1=CC(C(O)=O)=C(O)C=C1
• Target: PAK,Glutathione Peroxidase,Lipoxygenase,COX,Endogenous Metabolite,NF-κB,PPAR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (21.55 mM);Ethanol:29 mg/mL (189.37 mM);DMSO:80 mg/mL (522.4 mM)

Bioactivity

• Target IC50:
  contractile leukotriene:2.3 mM
• In Vivo:
  METHODS: To study the anti-tumor activity of 5-Aminosalicylic Acid, 5-Aminosalicylic Acid (50 mM) was administered to SCID mice inoculated with HT-29 colon cancer cells for 21 consecutive days. RESULTS: The tumor weight and volume of SCID mice treated with 5-Aminosalicylic acid were reduced by 80-86%.
• In Vitro:
  METHODS: HEK293 cells carrying the pendrin P123S mutant were treated with 5-Aminosalicylic Acid for 72 hours, and cytotoxicity was detected by the MTT method. RESULTS: The IC50 of 5-Aminosalicylic Acid on HEK293 cells carrying the pendrin P123S mutant was >15 mM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, COX, 5Aminosalicylic Acid, 5-Aminosalicylic Acid, 5-ASA, 5 Aminosalicylic Acid, ALOX5, PAK, NFkB, NF-kB, NFκB, NF-κB, Nuclear factor-κB, Nuclear factor-kappaB, MPO, inhibit, Glutathione Peroxidase, GlutathionePeroxidase, EndogenousMetabolite, Mesalazine, Mesalamine, Inhibitor, p21 activated kinases, PPARγ, PPAR, Peroxisome proliferator-activated receptors

Compound Identifiers

PubChem CID

4075