20-ethyl Prostaglandin E2

SKU: orb2283579

Description

20-Ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of Prostaglandin E2 (PGE2) characterized by an extended ω-chain due to two additional methylene carbon atoms. Compared to unoprostone, a clinically approved glaucoma medication and the only extensively studied prostaglandin analog sharing this structural modification, 20-ethyl PGE2 maintains the natural 15(S) allylic hydroxyl in its lower side chain, potentially enhancing its effectiveness. Unoprostone, despite being an F-series prostaglandin, exhibits reduced affinity for FP receptors because of its lower side chain modifications (13,14-dihydro-15-keto), which diminishes its medicinal potency. Notably, 20-ethyl PGE2's efficacy relative to unoprostone and its interaction with EP or other prostanoid receptors remains unconfirmed due to the lack of published ligand binding assays. E-type prostaglandins, including 20-ethyl PGE2, are broadly acknowledged for their inflammatory, cytoprotective, and diverse biological activities.

Key Properties

• CAS Number: 37492-24-3
• MW: 380.5
• Formula: C₂₂H₃₆O₅
• SMILES: C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCCCC)O)[C@H](O)CC1=O
• Target: Prostaglandin Receptor,Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Prostaglandin Receptor,Others