1-Azakenpaullone

SKU: orb1224272

Description

1-Azakenpaullone is an analog of kenpaullone and is a potent, selective GSK3β inhibitor with IC50 of 18 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=2.0 and 4.2 uM); stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells.

Key Properties

• CAS Number: 676596-65-9
• MW: 328.169
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₀BrN₃O
• SMILES: O=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4
• Target: GSK-3
• Solubility: DMSO: 61 mg/mL (185.9 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vitro:
  Real Time qPCR Cell line: human MSCs. Concentration: 3 μM. Incubation time: 48 h. Result: Increased gene expression of osteoblast-specific marker genes (ALP, OC, ON, COL1A1, and OPN).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-Azakenpaullone

Quick Database Links

Gene Symbol

GSK-3