Human IL-7 protein

• Catalog Number: orb107750
• Category: Proteins
• Description: Interleukin-7 (IL-7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. IL-7 binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation ofhematopoietic stem cells into lymphoid progenitor cells. It also stimulates proliferation of B cells, T cells and NK cells. MurineIL-7 has approximately 65% and 88% amino acid sequence identity with human and rat IL-7 and both proteins exhibit crossspeciesactivity. IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies andduring HIV infection.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 96% by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 17.4 kDa
• Target: IL-7
• Protein Sequence: DCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDANKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGRKPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 2% trehalose
• Alternative names: Human Interleukin-7 protein
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human IL-7 protein