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Catalog Number | orb545740 |
---|---|
Category | Proteins |
Description | Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. |
Reactivity | Human |
Tag | N-10×His |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Unconjugated |
MW | 18.6 kDa |
Target | IL-22 |
Source | Human IL-22, His Tag (orb545740) is expressed from human 293 cells (HEK293). It contains AA Ala 34 - Ile 179 (Accession # Q9GZX6-1). |
Expression System | HEK293 |
Biological Activity | Immobilized Human IL-22, His Tag at 5 μg/mL (100 μL/well) can bind Anti-Human IL-22 MAb with a linear range of 0.5-16 ng/mL (QC tested). |
Expression Region | Ala 34 - Ile 179 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_065386.1 |
Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | IL-22,IL-TIF,ZCYTO18 Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.6 kDa. The protein migrates as 28-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Immobilized Human IL-22, His Tag (Cat. No. orb545740) at 5 μg/mL (100 μL/well) can bind Anti-Human IL-22 MAb with a linear range of 0.5-16 ng/mL (QC tested).
> 97% as determined by SDS-PAGE and HPLC. | |
16.9 kDa | |
E.Coli |
Greater than 95% as determined by SDS-PAGE. | |
16.9 kDa | |
E.coli |
Unconjugated | |
90% | |
27.1 kDa | |
Human IL-20 R alpha Protein, His Tag (orb1184776) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Lys 250 (Accession # Q9UHF4-1). |
Unconjugated | |
95% | |
50.9 kDa | |
Human IL-22 R alpha 1, Fc Tag (orb1289953) is expressed from human 293 cells (HEK293). It contains AA His 16 - Thr 228 (Accession # Q8N6P7-1). |
Biotin | |
90% | |
20.3 kDa | |
Biotinylated Human IL-22, His, (orb735043) is expressed from human 293 cells (HEK293). It contains AA Ala 34 - Ile 179 (Accession # Q9GZX6-1). |
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