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Recombinant Human FGF4
Catalog Number: orb1921836
| Catalog Number | orb1921836 |
|---|---|
| Category | Proteins |
| Description | Fibroblast Growth Factor 4 (FGF4) is one of a family of 18 secreted canonical FGF proteins that interact with 4 signaling tyrosine kinase FGF receptors. FGF4 is most highly expressed in the embryonic ectoderm, axial, paraxial, and lateral plate mesoderm, and tailbud. The FGF4 subfamily (FGF4, 5, 6) bind to receptors expressed predominantly in mesenchymal tissues (FGFR1c, 2c, 3c, 4), and play important roles in the early stages of embryonic development and organogenesis. FGF signaling is required for proper embryonic axial growth and segmentation. In a mouse model, creation of a gain of function FGF4 copy to replace an inactive FGF 8 gene was able to rescue limb development; however, it also caused abnormal tissue deposition and postaxial polydactyly, highlighting that levels of FGF proteins throughout embryonic development must be properly controlled for normal limb formation. The signal transduction mediated by the FGF/FGFR4 axis is extremely complex, which includes PKC, ERK1/2, AKT, Src, and GSK3β signaling cascades. The homodimer of FGFR4 forms when binding to either canonical FGF subfamily members or FGF19 subfamily members. Heparin or heparin sulfate is required for the binding of canonical FGF subfamily members to FGFR4, whereas KLB acts as a co-receptor of FGFR4 to facilitate FGFR4 interacting with FGF19 subfamily members. When FGFR4 forms protein complexes with FGFs, it can be phosphorylated on three main tyrosine residues: Y642, Y643, and Y764. |
| Form/Appearance | Lyophilized Powder |
| Purity | ≥95% |
| MW | 19.2 kDa |
| Entrez | 2249 |
| UniProt ID | P08620 |
| Source | CHO Cell |
| Expression System | Eukaryotic cell |
| Biological Origin | Human |
| Endotoxins | ≤10 EU/mg |
| Storage | Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -87°C under sterile conditions after reconstitution. |
| Alternative names | Fibroblast Growth Factor 4, Transforming Protein K Read more... |
| Note | For research use only |
| Application notes | Application Notes: For research use only. Minimum Sample Size: 50μg/vial |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Human FGF4 protein (Active) [orb359152]
> 96% as determined by SDSPAGE and HPLC.
19.8 kDa
E.Coli
5 μg, 500 μg, 100 μg - Item 1 of 1
Human FGF-4 (136AA) Protein [orb1471743]
Greater than 95% as determined by reducing SDS-PAGE.
15.1 KDa
Mammalian
10 μg, 50 μg - Item 1 of 1
Human FGF4 protein [orb594752]
Greater than 95% as determined by SDS-PAGE.
16.9 kDa
E.coli
500 μg, 10 μg, 50 μg, 1 mg Recombinant Human Fibroblast growth factor 4 (FGF4) (Active) [orb2657919]
Greater than 95% as determined by SDS-PAGE.
19.3 kDa
Mammalian cell
10 μg, 50 μg, 1 mgHuman FGF4 protein [orb706939]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
E. coli
500 μg, 50 μg, 10 μg
