Human IL-20 Protein

• Catalog Number: orb1146995
• Category: Proteins
• Description: Interleukin-20 (IL-20) belongs to the family of IL-10-related cytokines, which includes IL-10, -19, -20, -22, -24 and -26. IL-20 induces STAT activation through two types of receptor complex, one of which it shares with IL-19, indicating that their biological activities may overlap. Both cytokines may play an important role in regulating the development and proper functioning of skin. IL-20 has also been shown to promote endothelial cell tube formation, suggesting that it may be involved in vascular vessel maturation and remodelling.
• Reactivity: Human
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 19.4 kDa
• Target: IL-20
• Source: Human IL-20, His Tag (orb1146995) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Glu 176 (Accession # Q9NYY1-1).
• Expression System: HEK293
• Biological Activity: Human IL-20, His Tag immobilized on CM5 Chip can bind Human IL-20 R alpha, Fc Tag (Cat. No. ILA-H525d) with an affinity constant of 4.42 μM as determined in a SPR assay (Biacore 8K) (QC tested).
• Expression Region: Leu 25 - Glu 176
• Endotoxins: 1.0 EU per μg
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH 7.4
• Alternative names: interleukin-20,IL10D,IL-20,interleukin 20,Cytokine
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 19.4 kDa. The protein migrates as 18 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

Human IL-20, His Tag immobilized on CM5 Chip can bind Human IL-20 R alpha, Fc Tag (Cat. No. orb1146994) with an affinity constant of 4.42 μM as determined in a SPR assay (Biacore 8K) (QC tested).