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Human GDNF protein
Catalog Number: orb107727
| Catalog Number | orb107727 |
|---|---|
| Category | Proteins |
| Description | Glial cell-derived neurotrophic factor, also known as GDNF is a small protein that potently promotes the survival of variousneuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Inaddition, GDNF is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GFRA2 andGDNF family receptor alpha 1. GDNF (monomer) contains seven conserved cysteine residues, one of which (Cys 101) is usedfor inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knotconfiguration. |
| Target | GDNF |
| Conjugation | Unconjugated |
| Buffer/Preservatives | Lyophilized from a 0.2 μm filtered concentrated solution in 20mM PB, 500mM NaCl, pH 6.4 |
| Purity | > 97% by SDS-PAGE and HPLC analyses. |
| Protein Sequence | MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLNVTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDDDLSFLDDNLV YHILRKHSAK RCGCI |
| MW | 15.2 kDa |
| Tested applications | HPLC, SDS-PAGE |
| Biological Origin | E.coli |
| Storage | Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles. |
| Alternative names | Human Glial Cell-derived Neurotrophic Factor prote Read more... |
| Note | For research use only |
SDS-PAGE analysis of Human GDNF protein
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Recombinant human GFRAL protein, C-His-Avi (HEK293) [orb1516445]
> 95% as determined by Tris-Bis PAGE; > 95% as determined by SEC-HPLC
Due to glycosylation, the protein migrates to 48-62 kDa based on Tris-Bis PAGE result.
50 μg - Item 1 of 1
- Item 1 of 1
Human GDNF Protein, hFc Tag [orb1173742]
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 41.2 kDa after removal of the signal peptide. The apparent molecular mass of GDNF-hFc is approximately 55-70 kDa due to glycosylation.
Mammalian
100 μg, 10 μg, 50 μg - Item 1 of 1
Human C6orf144 protein [orb358708]
Greater than 90% as determined by SDS-PAGE.
53.8 kDa
E.coli
20 μg, 1 mg, 100 μg
