Human GDNF protein

• Catalog Number: orb107727
• Category: Proteins
• Description: Glial cell-derived neurotrophic factor, also known as GDNF is a small protein that potently promotes the survival of variousneuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Inaddition, GDNF is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GFRA2 andGDNF family receptor alpha 1. GDNF (monomer) contains seven conserved cysteine residues, one of which (Cys 101) is usedfor inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knotconfiguration.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 97% by SDS-PAGE and HPLC analyses.
• Conjugation: Unconjugated
• MW: 15.2 kDa
• Target: GDNF
• Protein Sequence: MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLNVTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDDDLSFLDDNLV YHILRKHSAK RCGCI
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 20mM PB, 500mM NaCl, pH 6.4
• Alternative names: Human Glial Cell-derived Neurotrophic Factor prote
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human GDNF protein