H2AFX antibody

• Catalog Number: orb106887
• Category: Antibodies
• Description: Mouse monoclonal to H2AFX. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 980CT1.5.5
• Tested applications: IHC-P, WB
• Predicted Reactivity: Mouse, Zebrafish
• Reactivity: Human
• Isotype: IgG1
• Immunogen: Synthetic Peptide
• Dilution range: WB: 1:1000
• Form/Appearance: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
• Conjugation: Unconjugated
• MW: 15145
• Target: H2AX
• UniProt ID: P16104
• NCBI: NP_002096.1
• Alternative names: anti H2AFX antibody, anti H2AX antibody, anti Hist
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Immunohistochemical analysis of formalin-fixed and paraffin-embedded human prostate section using H2AFX antibody