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Catalog Number | orb348912 |
---|---|
Category | Antibodies |
Description | Rabbit monoclonal antibody to CD4 |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | MT310 |
Tested applications | FC, IF, IHC-P, IP, WB |
Reactivity | Human, Primate |
Isotype | IgG |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | CD4 |
UniProt ID | P01730 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | Leu3/T3; T-cell differentiation antigen; Ly-4; L3T Read more... |
Note | For research use only |
Application notes | mt310 can inhibit gp120 binding to CD4, which blocks HIV infectivity of CD4+ T lymphocytes, as well as the binding of MHCII, which results in the block of T-cell activation, possibly leading to the induction of anergy. Antibody binding to CD4 additionally causes the induction of GM-CSF, TNF-α (only after 20 h) and IL-10. |
Expiration Date | 12 months from date of receipt. |
Herzog, C. et al. Monoclonal anti-CD4 in arthritis Lancet, 2, 1461-1462 (1987)
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