Tec antibody

• Catalog Number: orb154251
• Category: Antibodies
• Description: Rabbit polyclonal antibody to Tec. Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx. Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH). Tecs TH domain interacts with the SH3 domain of Grb2, Src family PTKs ( Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tecs SH3 domain interacts with DC28 and has been shown to phosphorylate p62 dok, CD28 substrate. Tec can phosphorylate Jak kinase in hematopoietic cellsand can also be phosphorylated by Src member Lyn on multiple tyrosine residues.
• Clonality: Polyclonal
• Tested applications: ICC, IF, IHC, WB
• Reactivity: Human, Mouse, Rat
• Isotype: IgG
• Immunogen: Recombinant fusion protein of human Tec(NP_003206.2).
• Dilution range: WB: 1:500-2000
• Conjugation: Unconjugated
• MW: 68KDa
• UniProt ID: P42680
• Storage: Store at -20°C. Avoid freeze / thaw cycles.
• Buffer/Preservatives: PBS with 0.05% proclin300,50% glycerol,pH7.3.
• Alternative names: anti PSCTK4 antibody, anti Tyrosine-protein kinase
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of extracts of various cells using Tec antibody