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Catalog Number | orb1818798 |
---|---|
Category | Small Molecules |
Description | SMAD3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. Smad3 Inhibitor, SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts. |
CAS Number | [1009104-85-1] |
MW | 453.5322869 |
SMILES | CN1C2C(=CC=CN=2)C(/C=C/C(N2CCC3=C(C=C(C(OC)=C3)OC)C2)=O)=C1C1=CC=CC=C1 |
Formula | C28H27N3O3 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
FC, ICC, IHC-P, WB | |
Human, Mouse, Rat | |
Rabbit | |
Recombinant | |
Unconjugated |
IHC, WB | |
Human | |
Rabbit | |
Polyclonal | |
Unconjugated |
IF, IH, WB | |
Human, Mouse, Porcine, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
FC, ICC, IHC-P | |
Bovine, Canine, Equine, Porcine, Sheep | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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