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Catalog Number | orb1955573 |
---|---|
Category | Proteins |
Description | RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q68DV7-1. |
Tag | C-His |
Purity | 98.70% |
MW | 20.5 kDa (predicted); 27 and 23.8 kDa (reducing conditions) |
UniProt ID | Q68DV7 |
Expression System | HEK293 Cells |
Biological Origin | Human |
Biological Activity | RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q68DV7-1. |
Expression Region | A DNA sequence encoding the human RNF43 (NP_060233.3) (Met1-Tyr197) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Gly 24 |
Storage | -20°C |
Note | For research use only |
Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Expiration Date | 6 months from date of receipt. |
98.00% | |
34.2 kDa (predicted) |