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ZNRF3 Protein, Human, Recombinant (His)

ZNRF3 Protein, Human, Recombinant (His)

Catalog Number: orb1978639

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Catalog Numberorb1978639
CategoryProteins
DescriptionE3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
TagC-6xHis
Purity98.00%
MW20.4 kDa (predicted)
UniProt IDQ9ULT6
Protein SequenceKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDM
Expression SystemHEK293 Cells
Biological OriginHuman
Biological ActivityE3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
Expression Region56-219 aa
Storage-20°C
NoteFor research use only
Application notesReconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Expiration Date6 months from date of receipt.
  • ZNRF3 Protein, Human, Recombinant (His & SUMO) [orb1978640]

    98.00%

    34.2 kDa (predicted)

    1 mg, 100 μg, 20 μg
  • Human ZNRF3 Protein, His Tag [orb750350]

    Unconjugated

    95%

    19.7 kDa

    Human ZNRF3, His Tag (orb750350) is expressed from human 293 cells (HEK293). It contains AA Lys 56 - Met 219 (Accession # Q9ULT6-1).

    100 μg, 1 mg