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ZNRF3 Protein, Human, Recombinant (His & SUMO)

ZNRF3 Protein, Human, Recombinant (His & SUMO)

Catalog Number: orb1978640

DispatchUsually dispatched within 5-10 working days
$ 300.00
Catalog Numberorb1978640
CategoryProteins
DescriptionE3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
TagN-6xHis-SUMO
Purity98.00%
MW34.2 kDa (predicted)
UniProt IDQ9ULT6
Protein SequenceKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDM
Expression SystemE. coli
Biological OriginHuman
Biological ActivityE3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
Expression Region56-219 aa
Storage-20°C
NoteFor research use only
Application notesA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Expiration Date6 months from date of receipt.