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Catalog Number | orb612151 |
---|---|
Category | Proteins |
Description | Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease. |
Reactivity | Monkey |
Tag | C-10×His |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Unconjugated |
MW | 26.5 kDa |
Target | Complement Factor D |
Source | Rhesus macaque / Cynomolgus Complement Factor D, His Tag (orb612151) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Ala 253 (Accession # H9EXC1-1). In the region Ile 26 - Ala 253, the AA sequence of Rhesus macaque and Cynomolgus Complement Factor D are homologus. |
Expression System | HEK293 |
Expression Region | Ile 26 - Ala 253 |
Endotoxins | 1.0 EU per μg |
NCBI | XP_005587397.1 |
Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Buffer/Preservatives | 50 mM Tris, 150 mM NaCl, pH8.0 |
Alternative names | CFD,Adipsin,PFD,DF,Complement factor D Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.5 kDa. The protein migrates as 25-27 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Unconjugated | |
95% | |
51.0 kDa | |
Rhesus macaque Complement Factor D, Fc Tag (orb612140) is expressed from human 293 cells (HEK293) and inactive. It contains AA Ile 26 - Ala 253 (Accession # H9EXC1-1). |
WB | |
> 90% as determined by SDS-PAGE. | |
26.5 kDa | |
HEK293 cells |
WB | |
> 95% as determined by SDS-PAGE. | |
51.0 kDa | |
HEK293 cells |
98.00% | |
The protein has a predicted MW of 25.7 kDa. Due to glycosylation, the protein migrates to 26-30 kDa based on Tris-Bis PAGE result. |
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