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Catalog Number | orb612140 |
---|---|
Category | Proteins |
Description | Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease. |
Reactivity | Monkey |
Tag | C-Fc |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 51.0 kDa |
Target | Complement Factor D |
Source | Rhesus macaque Complement Factor D, Fc Tag (orb612140) is expressed from human 293 cells (HEK293) and inactive. It contains AA Ile 26 - Ala 253 (Accession # H9EXC1-1). |
Expression System | HEK293 |
Expression Region | Ile 26 - Ala 253 |
Endotoxins | 1.0 EU per μg |
NCBI | XP_005587397.1 |
Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Buffer/Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
Alternative names | CFD,Adipsin,PFD,DF,Complement factor D Read more... |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.0 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
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