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Catalog Number | orb67271 |
---|---|
Category | Antibodies |
Description | Rabbit polyclonal to REL.Proto-oncogene c-Rel EL) is a member of the NF-kappa-B transcription factor family. NF-kappa-Bis a pleiotropic transcription factor present in almost all cell types and is involved in many biologicalprocessed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.NF-kappa-B is a homo-or heterodimeric complex formed by the Rel-like domain-containing proteinsRELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind to the kappa-Bsites of their target genes and the individual dimers have distinct affinity and specificity for differentkappa-B sites. Different dimer combinations act as transcriptional activators or repressors,respectively. NF-kappa-B complexes are held in the cytoplasm in an inactive state by members of theNF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B isphosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequentlydegraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NFkappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
Species/Host | Rabbit |
Clonality | Polyclonal |
Tested applications | WB |
Reactivity | Human, Mouse |
Immunogen | C-terminal region of human REL |
Dilution range | WB:1:1000-1:5000 |
Purity | Affinity purification |
Conjugation | Unconjugated |
MW | 69 |
UniProt ID | Q04864 |
Storage | -20°C |
Buffer/Preservatives | 0.01% NaN3 |
Alternative names | anti-REL antibody,anti-Protooncogene cRel antibody Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Western blot analysis of total cell extracts from human Hela(Lane1)
FC, IHC-P, WB | |
Bovine, Canine, Porcine | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
FC, ICC, IHC-P | |
Bovine, Canine, Equine, Porcine | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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