Recombinant Human GM-CSF

• Catalog Number: orb1921840
• Category: Proteins
• Description: Granulocyte-monocyte colony-stimulating factor (GM-CSF) is a cytokine mostly acting as a hemopoietic growth factor on the proliferation and differentiation of myeloid cells from bone marrow progenitors. Besides its well-known hematopoietic role, GM-CSF is involved in the modulation of differentiation, polarization, and activation of immune cells such as macrophages, dendritic cells, and lymphocytes, resulting in a strong influence on the typical immune/inflammatory cascade of chronic autoimmune diseases. GM-CSF circulating levels are quite low in homeostatic conditions but can quickly rise in a few circumstances, such as infections or inflammation. In fact, several cell types can produce GM-CSF, including endothelial cells, macrophages, fibroblasts, DCs, neutrophils, eosinophils, resident tissue cells, T cells, and cancer cells. GM-CSF works through the binding to its receptor, a heterodimeric molecule composed of one α chain, specific for the ligand, and one β chain, specific for the transduction of the signal into the cell, which is shared with IL-3 and IL-5. Once GM-CSF binds to its receptor, the signal is transduced not only mainly through the JAK-2/STAT pathway but also through the mitogen-activated protein kinase (MAPK), nuclear factor (NF)-κB, and phosphatidylinositol 3 kinases (PI3K) pathways.
• Form/Appearance: Lyophilized Powder
• Purity: ≥95%
• UniProt ID: P04141
• MW: 14.4 kDa
• Application notes: Application Notes: For research use only. Minimum Sample Size: 50μg/vial
• Expression System: Eukaryotic cell
• Endotoxins: ≤10 EU/mg
• Source: CHO Cell
• Biological Origin: Human
• Storage: Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -83°C under sterile conditions after reconstitution.
• Alternative names: Granulocyte Colony-Stimulating Factor, Colony Stim
• Note: For research use only
• Entrez: 1437
• Expiration Date: 6 months from date of receipt.