Human SIGIRR Protein

• Catalog Number: orb1146969
• Category: Proteins
• Description: Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 39.0 kDa
• Target: SIGIRR
• Source: Human SIGIRR, Fc Tag (orb1146969) is expressed from human 293 cells (HEK293). It contains AA Met 1 - His 118 (Accession # Q6IA17-1).
• Expression System: HEK293
• Expression Region: Met 1 - His 118
• Endotoxins: 1.0 EU per μg
• NCBI: NP_068577.2
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: Single Ig IL-1-related receptor,Single Ig IL-1R-re
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.0 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.