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Human Dkk-1 Protein
Catalog Number: orb334894
| Catalog Number | orb334894 |
|---|---|
| Category | Proteins |
| Description | Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression. |
| Reactivity | Human |
| Tag | C-Fc |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 52.4 kDa |
| Target | Dkk-1 |
| Protein Sequence | NP_036374.1 |
| Source | Human Dkk-1, Fc Tag (orb334894) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1). |
| Expression System | HEK293 |
| Expression Region | Thr 32 - His 266 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_036374.1 |
| Storage | -20℃ |
| Buffer/Preservatives | PBS, pH7.4 |
| Alternative names | DKK1,SK Read more... |
| Note | For research use only |
| Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.4 kDa. The protein migrates as 67-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Human Dkk-1 protein
- Item 1 of 2
Human Dkk-1 Protein [orb257395]
Unconjugated
95%
26.6 kDa
Human Dkk-1 Protein, His Tag, premium grade (orb257395) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).
20 μg, 1 mg, 100 μg - Item 1 of 1
- Item 1 of 1
Human Dkk-3 (R335G) Protein [orb257976]
Unconjugated
95%
37.0 kDa
Human Dkk-3 (R335G), His Tag (orb257976) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).
20 μg, 200 μg 
Human DKK1 Protein, hFc Tag [orb1173930]
Unconjugated
The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 51.9 kDa after removal of the signal peptide.The apparent molecular mass of DKK1-hFC is approximately 70 kDa due to glycosylation.
Mammalian
100 μg, 10 μg, 50 μgHuman DKK1 protein [orb391620]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
Human cells
500 μg, 50 μg, 10 μg
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