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Catalog Number | orb545757 |
---|---|
Category | Proteins |
Description | Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases. |
Reactivity | Human |
Tag | C-10×His |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Unconjugated |
MW | 37.4 kDa |
Target | CTGF |
Source | Human CTGF, His Tag (orb545757) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ala 349 (Accession # Q5M8T4-1). |
Expression System | HEK293 |
Biological Activity | Loaded Monoclonal Anti-Human CTGF Antibody, Human IgG1 on AHC Biosensor, can bind Human CTGF, His Tag with an affinity constant of 6.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested). |
Expression Region | Gln 27 - Ala 349 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_001892.1 |
Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Buffer/Preservatives | Tris with Potassium glutamate and Arginine, pH7.0 |
Alternative names | CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding p Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.4 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Loaded Monoclonal Anti-Human CTGF Antibody, Human IgG1 on AHC Biosensor, can bind Human CTGF, His Tag (Cat. No. orb545757) with an affinity constant of 6.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Unconjugated | |
90% | |
61.9 kDa | |
Human CTGF, Fc Tag (orb867319) is expressed from human 293 cells (HEK293). It contains AA Gln27-Ala349 (Accession # Q5M8T4-1 ). |
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC | |
KMP1937, Recombinant Human CTGF / CCN2 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gln27-Ala349) of Human CTGF / CCN2 fused with a His Tag at the C-terminal. |
≥90% as determined by SDS-PAGE | |
This protein contains the human CTGF(Gln27-Ala349) was fused with the C-terminus Fc Tag and expressed in Mammalian cells. |
≥90% as determined by SDS-PAGE | |
This protein contains the human CTGF(Gln27-Ala180) was fused without Tag and expressed in Mammalian cells. |
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