Glucocorticoid receptor agonist-1

SKU: orb1692476

Description

Glucocorticoid receptor agonist-1 is a high-affinity synthetic ligand for the GR, exhibiting potent agonist activity with an IC50 of 2.8 nM. It is a valuable research tool for studying glucocorticoid receptor signaling and its roles in inflammation, metabolism, and stress response in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2166375-82-0
• MW: 569.69
• Purity: 99.16% (May vary between batches)
• Formula: C₃₅H₃₉NO₆
• SMILES: [H][C@]1(O[C@]2([H])C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO)c1ccc(Cc2cccc(N)c2)cc1
• Target: Glucocorticoid Receptor,ADC Cytotoxin
• Solubility: DMSO:50 mg/mL (87.77 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (4.39 mM)

Bioactivity

• Target IC50:
  GR:2.8 nM (IC50)
• In Vitro:
  Glucocorticoid receptor agonist-1 (Compound 41) is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Cytotoxin, ADCCytotoxin, Glucocorticoid Receptor, Glucocorticoid receptor agonist 1, Glucocorticoid receptor agonist1, Glucocorticoid receptor agonist-1, GlucocorticoidReceptor

Compound Identifiers

PubChem CID

134491939