Ephrin Type A receptor 2 antibody

• Catalog Number: orb348860
• Category: Antibodies
• Description: Human monoclonal antibody to Ephrin Type A receptor 2
• Species/Host: Human
• Clonality: Monoclonal
• Clone Number: 1C1
• Tested applications: ELISA, FC, IF, WB
• Reactivity: Human
• Isotype: IgG1
• Immunogen: 1C1 was isolated after screening of a non-immunized human Fab phage library. Selection was based on the ability to bind soluble human recombinant EphA2 (residues 183-510). The Fab was subsequently converted to full length human IgG1.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: Human Ephrin Type A receptor 2
• UniProt ID: P29317
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: EphA2; Epithelial cell kinase; Tyrosine-protein ki
• Note: For research use only
• Application notes: This antibody binds to human Ephrin type-A receptor 2, a receptor tyrosine kinase that binds to membrane-bound ephrin-A ligands residing on adjacent cells, triggering contact-dependent signaling into neighboring cells. Eph2A is involved in pattern formation during development, angiogenesis and osteoblastogenesis. Eph2A has also been found to be expressed in a variety of cancers. This antibody acts as an agonist of Eph2A signaling. The agonist properties of 1C1 is due to ligand mimicry by VDR3. After cell binding, the antibody is able to induce rapid tyrosine phosphorylation, internalization, and degradation of the EphA2 receptor.
• Expiration Date: 12 months from date of receipt.

References

Peng, Li et al. Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody J Mol Biol, 413, 390-405 (2011)

PubMed: 21867711