E Cadherin Antibody

• Catalog Number: orb1906359
• Category: Antibodies
• Description: E Cadherin Antibody
• Species/Host: Rabbit
• Clonality: Monoclonal
• Clone Number: 56-4
• Tested applications: ELISA, Functional Studies
• Reactivity: Mouse
• Isotype: IgG1
• Immunogen: The original antibody was generated by immunizing rabbits with purified extracellular domain of mouse E-cadherin.
• Concentration: 1 mg/ml
• Conjugation: Unconjugated
• Target: E Cadherin
• UniProt ID: P09803
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: CD324; ARC-1; Cdh1; Cadherin-1; Cadherin E; E-Cadh
• Note: For research use only
• Application notes: The binding of this antibody to mouse E-cadherin results in its activation. The initial binding characterization of this antibody to mouse E-cadherin was done using ELISA. This antibody was used to study the effect of activation of mouse E-cadherin on the growth and metastasis of a spontaneous breast cancer mouse model. Female MMTV-PyMT and control mice treated with 5 mg/kg of this antibody developed tumors in all 10 mammary glands. Also the number of metastasis nodules was significantly reduced with treatment with 56-4 activating antibody (PMID: 32127478; WO2020243616).
• Expiration Date: 12 months from date of receipt.