CTNNB1 antibody

• Catalog Number: orb106921
• Category: Antibodies
• Description: Rabbit polyclonal to CTNNB1. Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Clone Number: RB41157
• Tested applications: WB
• Predicted Reactivity: Mouse, Other, Rat, Zebrafish
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: Synthetic Peptide
• Dilution range: WB: 1:1000
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• MW: 85497
• Target: CTNNB1
• UniProt ID: P35222
• NCBI: NP_001895.1, NP_001091679.1, NP_001091680.1
• Alternative names: anti CTNNB1 antibody, anti CTNNB antibody, anti Ca
• Note: For research use only
• Expiration Date: 12 months from date of receipt.