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Catalog Number | orb749499 |
---|---|
Category | Antibodies |
Description | This mAb recognizes a protein of ~30kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B), or Elastase 3B. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six genes which encode the structurally similar proteins: Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, 3B has little elastolytic activity. Like most of the human elastases, 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. It may also function in the intestinal transport and metabolism of cholesterol. Elastases 3A/B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | CELA3B/1218 |
Tested applications | ELISA, WB |
Reactivity | Human |
Isotype | Mouse IgG1, kappa |
Immunogen | A partial recombinant protein (aa 82-238) was used as the immunogen for the CELA3B antibody. |
Dilution range | ELISA: 2-4ug/ml (order BSA/azide-free format),Western blot: 0.5-1ug/ml |
Purity | Protein G affinity chromatography |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
Hazard Information | This CELA3B antibody is available for research use only. |
UniProt ID | P08861 |
Storage | Store the CELA3B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide). |
Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide |
Note | For research use only |
Application notes | Optimal dilution of the CELA3B antibody should be determined by the researcher. |
Expiration Date | 12 months from date of receipt. |
IHC-P | |
Human, Mouse, Rat | |
Mouse | |
Monoclonal | |
Unconjugated |
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