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CD4 Antibody: T Cell Marker & Immunophenotyping Tool for Immunology Research
Essential for T cell activation, immune response regulation, and widely studied in autoimmune diseases, HIV/AIDS, and cancer immunology.
Overview of CD4
CD4 is a critical cell surface marker found on T-helper cells (Th), regulatory T cells (Tregs), and a subset of monocytes. It plays an essential role in T cell activation, immune response regulation, and is widely studied in autoimmune diseases, HIV/AIDS, and cancer immunology.
Biorbyt offers a comprehensive range of CD4 antibody, including flow cytometry-compatible antibody for detecting and quantifying CD4-positive cells. Our product is validated for flow cytometry, immunohistochemistry (IHC), western blot (WB), and ELISA, ensuring reliable results in diverse applications across immunology and cancer research.
What is CD4 and Its Importance in Immunology?
CD4 is a glycoprotein expressed on the surface of T-helper cells (Th cells), regulatory T cells (Tregs), and monocytes. It functions as a co-receptor for the T cell receptor (TCR), helping T cells interact with MHC class II molecules on antigen-presenting cells (APCs), thus activating T cells and triggering immune responses. CD4 plays a critical role in immune regulation, T cell activation, and cytokine production. CD4 antibody is a crucial tool for immune profiling, HIV/AIDS research, autoimmunity, and cancer immunotherapy.
Emerging Research Directions for CD4
Recent studies are increasingly focusing on CD4's involvement in immunotherapies and tumor immunity. Notable emerging areas include:
- CD4 in Cancer Immunotherapy: Research explores how CD4+ T cell regulates anti-tumor immunity and how targeting CD4+ T cell can enhance immune checkpoint inhibitors in cancer treatment.
- CD4 in HIV Vaccine Development: CD4 antibody is pivotal in vaccine development and immune reconstitution studies in HIV research.
- CD4 in Stem Cell Research: Investigating the role of CD4+ T cell in stem cell therapies and their potential for immune modulation in tissue regeneration.
Biorbyt's CD4 antibody is validated in these new research contexts, helping scientists stay ahead in cutting-edge immune system research.
Recommended CD4 Antibody for Your Research
Biorbyt provides a wide range of CD4 antibody validated for flow cytometry, immunohistochemistry, and other immunological applications. Below is the top-performing CD4 antibody based on specific research needs:
SKU | Product Name | Key Advantage | Applications | Size | Price |
|---|---|---|---|---|---|
Anti-CD4 [MT310] Mouse Monoclonal Antibody (Best for flow cytometry), Literature Support | High specificity for human and primate CD4 | Blocking, FC, IF, IHC-P, IP, NeA | 0.2 mg | $600 | |
Anti-CD4 [13B8.2 (IOT4a) ]Mouse Monoclonal Antibody, Literature Support | Suitable for flow cytometry and IHC-Fr | EIA, ELISA, FC, IHC-Fr, WB | 0.2 mg | $600 | |
CD4 Mouse Monoclonal Antibody [8G1B12], Literature Support | Ideal for human, mouse, and rat reactivity | ELISA, IF, IHC-P, WB | 0.02 mg | $240 | |
CD4 Recombinant Rabbit Monoclonal Antibody | Recombinant antibody for consistent performance | FC, IF, IHC-Fr, IHC-P, WB | 25 μl | $220 | |
CD4 Rabbit Polyclonal Antibody | Broad reactivity in human, mouse, and porcine models | FC, IF, IHC-Fr, IHC-P, WB | 50 μl | $250 |
Applications of CD4 Antibody
CD4 antibody is essential for the following applications:
- Flow Cytometry (FC): CD4 antibody is widely used in flow cytometry to quantify CD4+ T cell and analyze T-helper cell activation. It is essential for detecting T cell subsets, such as naïve, memory, and effector T cells, and for assessing immune responses in disease models like HIV and autoimmunity.
- Immunoprecipitation (IP): Use CD4 antibody in IP to pull down CD4+ protein complexes and study protein-protein interactions. This is essential for understanding T cell signaling pathways, cytokine production, and how CD4+ T cell interact with other immune cells or pathogens.
- Neutralization Assays (NeA): CD4 antibody is used to block CD4 interactions with its ligands, such as HIV and MHC II molecules. This is key for studying immune modulation and HIV infection mechanisms, and to evaluate immune checkpoint inhibitors or HIV therapies.
- Enzyme Immunoassay (EIA): CD4 antibody is utilized in EIA to quantify soluble CD4 in serum or plasma. This application is commonly used in HIV/AIDS research, autoimmune disease monitoring, and for evaluating immune responses in vaccine studies.
- Blocking Assays: Blocking assays are used to modulate immune responses by blocking the CD4 receptor. This is crucial in HIV/AIDS and cancer immunotherapy research, where CD4 plays a role in immune suppression or immune checkpoint modulation.
How to Choose the Right CD4 Antibody for Your Research
When selecting a CD4 antibody, consider the following:
- Application: Choose an antibody that is validated for your specific research method, such as flow cytometry, immunoprecipitation, or neutralization assays.
- Species Reactivity: Ensure the antibody is validated for the species you are studying (e.g., human, mouse, rat, or primate).
- Antibody Type: Depending on your needs, select between monoclonal antibody (for high specificity) or polyclonal antibody (for broader reactivity).
- Performance: Choose an antibody with extensive validation in your application (e.g., IP, WB, IHC, EIA).
- Conjugation: For flow cytometry, select fluorochrome-conjugated antibody, and for other assays like IP or WB, choose unconjugated antibody.
Why Choose Biorbyt CD4 Product?
- ✔ High-quality CD4 antibody optimized for flow cytometry, IHC, WB, and EIA
- ✔ Recombinant monoclonal antibody for consistent performance across batches
- ✔ Citation-supported antibody for reliable research results
- ✔ Validated in multiple applications including blocking assays, IP, and neutralization
- ✔ Expert technical support for all applications
FAQ -- CD4 Research
What is CD4?
CD4 is a glycoprotein found on T-helper cell, Treg, and monocyte, crucial for immune signaling and T cell activation.
How is CD4 used in flow cytometry?
CD4 flow cytometry antibody is used to detect and quantify CD4+ T cell in blood, tissues, or cell suspensions.
What are CD4 T cells?
CD4 T cell are helper T cells that assist in immune responses and activate other immune cells in response to pathogens and infections.
Is CD4 specific for T-helper cells?
Yes, CD4 is primarily expressed on T-helper cell, Treg, and monocyte, making it a key marker for these immune cell types.
What is the difference between CD4 and CD8?
CD4+ T cell are helper T cells, whereas CD8+ T cell are cytotoxic and directly kill infected or cancerous cells.
Which CD4 antibody should I choose?