CD30 antibody

• Catalog Number: orb348857
• Category: Antibodies
• Description: Mouse monoclonal antibody to CD30
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: Ki-4
• Tested applications: ELISA, FC, IF, IHC
• Reactivity: Human
• Isotype: IgG1
• Immunogen: Human CD30.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: CD30
• UniProt ID: P28908
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: TNFRSF8; Tumor necrosis factor receptor superfamil
• Note: For research use only
• Application notes: The antibody binds specifically to CD30, a cell membrane protein which belongs to the tumour necrosis factor receptor family. Incubation of CD30 positive L540 cells with Ki-4 antibody completely inhibits release of soluble CD30 (in contrast to Ki-3, Ab00474). CD30 is expressed on activated lymphocytes, and binding by its ligands TRAF2 and TRAF5 results in the activation of NF-kappaB, thereby regulating gene expression. CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma.
• Expiration Date: 12 months from date of receipt.

References

Horn-Lohrens, O. et al. Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4) Int J Cancer, 60, 539-544 (1995)

PubMed: 7530238