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Catalog Number | orb348925 |
---|---|
Category | Antibodies |
Description | Mouse monoclonal antibody to CD30 |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | Ki-3 |
Tested applications | ELISA, FC, IF, IHC |
Reactivity | Human |
Isotype | IgG2b |
Immunogen | Human CD30. |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | CD30 |
UniProt ID | P28908 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | TNFRSF8; Tumor necrosis factor receptor superfamil Read more... |
Note | For research use only |
Application notes | The antibody binds specifically to CD30, a cell membrane protein which belongs to the tumour necrosis factor receptor family. Incubation of CD30 positive L540 cells with Ki-3 antibody weakly enhances release of soluble CD30 (in contrast to Ki-4, Ab00475). CD30 is expressed on activated lymphocytes, and binding by its ligands TRAF2 and TRAF5 results in the activation of NF-kappaB, thereby regulating gene expression. CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma. |
Expiration Date | 12 months from date of receipt. |
Horn-Lohrens, O. et al. Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4) Int J Cancer, 60, 539-544 (1995)
Flow-cytometry on Jurkat cells using CD30 antibody.
Immunohistochemical staining human tonsil tissue using CD30 antibody.
FC, ICC, IHC, IP, WB | |
Human | |
Rabbit | |
Recombinant | |
Unconjugated |
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