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Calbindin Antibody / CALB1

Catalog Number: orb2643573

DispatchUsually dispatched within 5-10 working days
$ 780.00
Catalog Numberorb2643573
CategoryAntibodies
DescriptionThe family of EF-hand type Ca2+-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 and , Calgranulin A (also designated MRP8), Calgranulin B (also designated MRP14), Calgranulin C and the Parvalbumin family members, including Parvalbumin and Parvalbumin (also designated oncomodulin). Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261-amino acid protein with 6 EF-hand domains, 4 of which are active calcium-binding domains. Expressed in brain, ovary, uterus, testis, pancreas, liver, kidney and intestine, Calbindin D28K acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function.
Species/HostMouse
ClonalityMonoclonal
Clone NumberCALB1/3333
Tested applicationsELISA, IHC-P
ReactivityHuman
IsotypeMouse IgG2b, kappa
ImmunogenA recombinant human partial protein (amino acids 7-96) was used as the immunogen for this CALB1 antibody.
Antibody TypePrimary Antibody
Dilution rangeELISA (order BSA-free format for coating),Immunohistochemistry (FFPE): 1-2ug/ml
PurityProtein G affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis CALB1 antibody is available for research use only.
UniProt IDP05937
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
Calbindin Antibody / CALB1

IHC staining of FFPE human kidney with CALB1 antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

Calbindin Antibody / CALB1

IHC staining of FFPE human kidney with CALB1 antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

Calbindin Antibody / CALB1

Analysis of HuProt (TM) microarray containing more than 19000 full-length human proteins using CALB1 antibody (clone CALB1/3333). These results demonstrate the foremost specificity of the CALB1/3333 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

Calbindin Antibody / CALB1

SDS-PAGE analysis of purified, BSA-free CALB1 antibody as confirmation of integrity and purity.

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