Bax Antibody

• Catalog Number: orb1732754
• Category: Antibodies
• Description: Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 2A3
• Tested applications: WB
• Reactivity: Human, Monkey
• Isotype: Mouse IgG2a
• Immunogen: Purified recombinant human Bax protein fragments expressed in E.coli
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000
• Conjugation: Unconjugated
• MW: Calculated MW: 21 kDa; Observed MW: 21 kDa
• Entrez: 581
• UniProt ID: Q07812
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: Apoptosis regulator BAX; BAX; Bcl-2-like protein 4
• Note: For research use only
• Expiration Date: 12 months from date of receipt.